Protein Homology Detection Through Alignment of Markov Random Fields: Using MRFalign – FULL INSTANT DOWNLOAD | PDF DOCX EPUB

Name: Protein Homology Detection Through Alignment of Markov Random Fields: Using MRFalign
ISBN-13: 9783319149134
ISBN-10: 331914913X
Addition ISBN: 3319149148, 9783319149141
Author(s): Jinbo Xu; Sheng Wang; Jianzhu Ma, Publisher: Springer, Copyright: 2015
This work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) based methods, and then describes a novel Markov Random Fields (MRF) based method developed by the authors. MRF-based methods are much more sensitive than HMM- and PSSM-based methods for remote homolog detection and fold recognition, as MRFs can model long-range residue-residue interaction. The text also describes the installation, usage and result interpretation of programs implementing the MRF-based method.